From the Literature

Published: Sep 2015

Hunt BJ, Allard S, Keeling D, Norfolk D, Stanworth SJ, Pendry K

A practical guideline for the haematological management of major haemorrhage.
Br J Haematol 2015;170:788-803.

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NATA REVIEW:
Hunt et al. set the standards in a practical guideline from the British Committee for Standards in Haematology....
REVIEW by:
J. Stensballe

Published: Aug 2015

Douketis JD, Spyropoulos AC, Kaatz S, et al.

Perioperative bridging anticoagulation in patients with atrial fibrillation.
N Engl J Med 2015;373:823-833.

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NATA REVIEW:
Perioperative management of anticoagulation is sometimes complex and challenging. Different factors influencing...
REVIEW by:
D. Faraoni

Published: Aug 2015

Pollack CV, Jr., Reilly PA, Eikelboom J, et al.

Idarucizumab for dabigatran reversal.
N Engl J Med 2015;373:511-520.

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NATA REVIEW:
Dabigatran etexilate, a direct thrombin inhibitor, has been increasingly used over the last few years, but the...
REVIEW by:
D. Faraoni

Published: Aug 2015

Glund S, Stangier J, Schmohl M, et al.

Safety, tolerability, and efficacy of idarucizumab for the reversal of the anticoagulant effect of dabigatran in healthy male volunteers: a randomised, placebo-controlled, double-blind phase 1 trial.
Lancet 2015;386:680-690.

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NATA REVIEW:
Dabigatran etexilate is a direct thrombin inhibitor increasingly used for stroke prevention in patients with...
REVIEW by:
D. Faraoni

Published: Aug 2015

Caldeira D, Rodrigues FB, Barra M, et al.

Non-vitamin K antagonist oral anticoagulants and major bleeding-related fatality in patients with atrial fibrillation and venous thromboembolism: a systematic review and meta-analysis.
Heart 2015;101:1204-1211.

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NATA REVIEW:
Non-vitamin K antagonist oral anticoagulants (NOACs) are alternatives to vitamin K antagonists (VKAs) for the...
REVIEW by:
F. Bonhomme

Published: Jul 2015

Clark NP, Witt DM, Davies LE, et al.

Bleeding, recurrent venous thromboembolism, and mortality risks during warfarin interruption for invasive procedures.
JAMA Intern Med 2015;175:1163-1168.

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NATA REVIEW:
Preoperative management of patients treated with vitamin K antagonists who require elective surgical procedures...
REVIEW by:
D. Faraoni

Published: Jul 2015

Whiting P, Al M, Westwood M, et al.

Viscoelastic point-of-care testing to assist with the diagnosis, management and monitoring of haemostasis: a systematic review and cost-effectiveness analysis.
Health Technol Assess 2015;19:1-228.

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NATA REVIEW:
This study from the UK's Health and Technology Assessment group looked at all the available evidence on clinical...
REVIEW by:
D. Thomas

Published: Jul 2015

Curry N, Rourke C, Davenport R, et al.

Early cryoprecipitate for major haemorrhage in trauma: a randomised controlled feasibility trial.
Br J Anaesth 2015;115:76-83.

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NATA REVIEW:
In this unblinded randomised controlled trial that enrolled 43 adult trauma patients at two major UK civilian...
REVIEW by:
S. R. Ostrowski

Published: Jul 2015

Parry-Jones AR, Di Napoli M, Goldstein JN, et al.

Reversal strategies for vitamin K antagonists in acute intracerebral hemorrhage.
Ann Neurol 2015;78:54-62.

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NATA REVIEW:
Intracerebral haemorrhage is the most dreaded complication of anticoagulant treatment with vitamin K antagonists....
REVIEW by:
M. Levi

Published: Jun 2015

Novikova N, Hofmeyr GJ, Cluver C

Tranexamic acid for preventing postpartum haemorrhage.
Cochrane Database Syst Rev 2015;6:CD007872.

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NATA REVIEW:
This Cochrane review systematically reviewed all the RCTs on the use of tranexamic acid in postpartum haemorrhage....
REVIEW by:
B. J. Hunt

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