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Use of recombinant factor Vlla (NovoSeven((R))) to reduce postoperative bleeding after total hip arthroplasty in a patient with cirrhosis and thrombocytopenia.

The role of rFVIIa in improving hemostasis in patients with chronic liver disease and/or thrombocytopenia has been reported in many case reports. This article is reporting a 59 yr old woman with liver cirrhosis and thrombocytopenia who suffered with profuse bleeding post total hip replacement. The patient was receiving red cell reinfusion using a cell […]

Recombinant factor VIIa improves clot formation but not fibrolytic potential in patients with cirrhosis and during liver transplantation.

Etiology of bleeding in cirrhotic patients during surgery is multifactorial, and its management includes several measures such as replacement of coagulation factors and platelets as well as the use of antifibrinolytic agents. Recombinant factor VIIa has been shown to normalize prothrombin time in patients with liver disease and to reduce transfusion requirement during OLT. In […]