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The interaction between platelets and factor VII/VIIa.

This is a clearly written article detailing the mechanism of action of rFVIIa and its interaction with tissue factor and platelets leading to its hemostatic effect in hemophilia patients with inhibitors and those with platelet disorders. – Maadh Aldouri

The use of recombinant factor VIIa in children with inherited platelet function disorders.

This is an interesting report on a small series of children with inherited platelet dysfunction treated with rFVIIa for acute bleeding or preoperatively. Response seemed to correlate with type of underlying condition, severity of bleeding and delay in presentation. In this series rFVIIa had variable efficacy in securing hemostasis. There was no difference in requirement […]

Managing uncontrolled hemorrhage in trauma and surgery: a novel and promising approach.

This is an introduction for a supplement to the Canadian Journal of Anesthesia reporting proceedings of a satellite symposium presented at the 2002 Canadian Anesthesiologists’ Society Annual Meeting. It highlights the role of rFVIIa in managing bleeding in hemophilia patients with inhibitors, and the increasing number of case reports and studies in its role in […]

Efficacy of recombinant factor VIIa administered by continuous infusion to haemophilia patients with inhibitors.

This is an interesting study looking at the efficacy of administering rFVIIa in controlling bleeding in 43 episodes in 14 hemophilia patients with inhibitors. RFVIIa infusion was not effective in controlling oral bleeding, but effective in controlling bleeding in other sites. The authors postulate that rFVIIa infusion was not effective in activating thrombin activatable fibrinolysis […]

The effect of recombinant factor VIIa on coagulopathic pigs with grade V liver injuries.

This study illustrates one of the unusual situations in Medicine where evidence of drug efficacy in human preceded animal studies. After the publication of several case reports on the effectiveness of rFVIIa in controlling traumatic bleeding, this study proves its efficacy in reducing bleeding after grade V liver injury in hypothermic dilutionally coagulopathic pigs, as […]

Continuous infusion of coagulation factor products.

This is an interesting review on the use of continuous infusion of coagulation factor products over the last 11 years. It concludes that effects were favorable in comparison to intermittent bolus infusions. It suggests that continuous infusion has the advantage of maintaining a therapeutic level of the factor, and is associated with decrease in factor […]

Massive pseudotumour resection with recombinant factor VIIa (NovoSeven) cover.

This is an interesting case report on the use of rFVIIa in covering surgical resection of a large right gluteal pseudo-tumor in a 32-year-old patient with severe hemophilia A and high-titer inhibitor. Factor VIIa was administered for 72 hours and monitored with measurement of PT and factor VII coagulation activity, and the latter was found […]

Potential role for rFVIIa in transfusion medicine.

This a thorough and comprehensive review on the mechanism of action and various indications and uses of rFVIIa, highlighting the pivotal role of factor VII in hemostasis, as well as the efficacy and safety of rFVIIa. – M. Aldouri.

Use of recombinant factor VII in hepatology.

This article starts with a general overview on mechanism of action, uses and safety of rFVIIa as well as the hemostatic disorders which are associated with liver disease. It states the correlation between the degree of liver damage and level and gene expression of FVII. The authors reviewed the use of rFVIIa in liver disease […]

Use of recombinant factor VIIa in hereditary bleeding disorders.

This is another excellent review of the mechanism of action, indications, and various doses of rFVIIa (Novoseven) in hereditary bleeding disorders. Its main use has been in patients with factor VIII or IX deficiency with inhibitors, where rFVIIa can by-pass factors VIII or IX, interacts with tissue factor and generates thrombin in addition to activating […]