Hyperoxic ventilation reduces 6-hour mortality at the critical hemoglobin concentration.
This experimental study convincingly demonstrates that hyperoxic ventilation of pigs diluted to the individual critical hematocrit is able to guarantee oxygenation of the vital organs and thereby allows survival. One […]
Risk of recurarization during retransfusion of autologous blood withdrawn after injection of muscle relaxants: A comparison of rocuronium and mivacurium.
Important information concerning the risk of recurarization when mivacurium and rocuronium have been administered prior to the removal of autologous blood in ANH. The anesthetist should be aware of this […]
Normovolemic hemodilution with Hb vesicle solution attenuates hypoxia in ischemic hamster flap tissue.
Encapsulation of human hemoglobin in liposome vesicles represents a useful method to attenuate the vasoactivity observed with conjugated or polymerized hemoglobin solutions currently under experimental and clinical investigation. Another advantage […]
Improved oxygenation in ischemic hamster flap tissue is correlated with increasing hemodilution with Hb vesicles and their O2 affinity.
Encapsulation of human hemoglobin in liposome vesicles represents a useful method to attenuate the vasoactivity observed with conjugated or polymerized hemoglobin solutions currently under experimental and clinical investigation. Another advantage […]
New mathematical model for the correct prediction of the exchangeable blood volume during acute normovolemic hemodilution.
In this rather complex article, the authors describe a new mathematical model that can be used to predict the exchangeable blood volume during acute normovolemic hemodilution. This model was validated […]
Heart rate increases linearly in response to acute isovolemic anemia.
From data collected in different earlier studies, the authors confirm their hypothesis that, in unmedicated healthy humans, heart rate increases linearly in response to acute isovolemic hemodilution. The authors also […]
The influence of crystalloid and colloid replacement solutions in acute normovolemic hemodilution: a preliminary survey of hemostatic markers.
This prospective randomized single blinded study nicely showed the dual effects of plasma substitutes used in acute normovolemic hemodilution. Solutions that have an impact on hemostasis like dextran and high […]
A prospective randomized study comparing two techniques of perioperative blood conservation: Isovolemic hemodilution and hypervolemic hemodilution.
This prospective randomized study reports that hypervolemic hemodilution using urea-linked gelatin is as efficient as moderate isovolemic hemodilution in reducing allogeneic blood exposure in ASA I and II patients undergoing […]
A mathematical model of cell salvage efficiency.
In this excellent paper, the authors develop a mathematical model that may help our understanding of the efficiency of blood salvage. The basic insights from these theoretical considerations are that […]
How effective is acute normovolaemic haemodilution in femoro-distal bypass surgery?
This case control cohort study reports that the efficacy of acute normovolemic hemodilution as a blood conservation technique appears limited due to the usually poor clinical status of patients undergoing […]
Acute normovolaemic haemodilution beyond a haematocrit of 25%: ratio of skeletal muscle tissue oxygen tension and cardiac index is not maintained in the healthy dog.
This experimental study investigates the effects of stepwise acute normovolemic hemodilution on muscular oxygen delivery in healthy anesthetized dogs. – Philippe Van der Linden
Identifying patients for blood conservation strategies.
This retrospective study nicely demonstrates that the use of a simple algorithm taking into account the type of operation and the preoperative hemoglobin concentration can be effective in identifying patients […]
Retrograde autologous priming of the cardiopulmonary bypass circuit reduces blood transfusion after coronary artery surgery.
This article confirms previous studies showing that a reduction of the bypass circuit priming volume can be associated with a reduction in allogeneic blood use. This beneficial effect is related […]
Perioperative hemodilution.
This is an interesting review article on the use of acute normovolemic hemodilution as part of a blood conservation strategy in patients undergoing elective surgery. – P. Van der Linden
Place of normovolemic hemodilution in oncologic cervicofacial and ENT surgery. [Article in French]
This prospective study did not demonstrate a beneficial effect of acute normovolemic hemodilution (ANH) in patients undergoing cervicofacial and ENT surgery. However, it does not possess the statistical power to […]