Effects on brain edema of crystalloid and albumin fluid resuscitation after brain trauma and hemorrhage in the rat.
The authors conducted an experimental study in rat traumatic brain injury showing that colloids lead to lesser brain edema. The study was well conducted but, obviously, clinical studies are needed […]
A comparison of albumin and saline for fluid resuscitation in the intensive care unit.
Essential reading material. The largest PRCT of Albumin vs Saline in 7,000 critically ill patients in Australia and New Zealand. Concludes “no-difference” in 28 day mortality. Subset trends to excess […]
Does priming implementation with low-dose albumin reduce postoperative bleeding following cardiopulmonary bypass?
Concludes that addition of Albumin to crystalloid prime reduces bleeding following cardiac by-pass surgery. At first glance looks like a big study (n=154 with crystalloid and low dose 20% albumin […]
In vivo effect of haemodilution with saline on coagulation: a randomized controlled trial.
The study design does not explore the possibility that hemorrhage and/or hypovolemia could contribute to hypercoagulability, as control group had no blood withdrawn. It would be good to see further […]
The effects of hydroxyethyl starches of varying molecular weights on platelet function.
This article is of interest in clinical decision-making related to starches usage. However, its interest is even higher for researchers in the field of volume replacement. – M. Mythen.
Hemostatic changes in patients receiving hydroxyethyl starch: The influence of ABO blood group.
This article is of interest in clinical decision-making related to starches usage. However, its interest is even higher for researchers in the field of volume replacement. – M. Mythen.