Clinical significance of RBC alloantibodies and autoantibodies in sickle cell patients who received transfusions.
The study shows that transfusion of blood matched for Rh and Kell systems would reduce alloimmunization to 27% and reduce delayed hemolytic transfusion reaction, but would not prevent it. Delayed hemolytic transfusion reactions were mild and did not cause hyperhemolysis in sickle cell patients. However, the cause of hyperhemolysis, which is a severe problem, was […]
Prospective RBC phenotype matching in a stroke-prevention trial in sickle cell anemia: a multicenter transfusion trial.
For a transfusionist from West/North Europe, the results are predictable and the conclusion expectable. In Germany, the prospective RBC phenotype matching in sickle cell anemia and thalassemia, and even in patients with chronic anemia, has been performed for many years (at least for C, c, E, e, K) and does not pose major problems. It […]