Heparin-level-based anticoagulation management during cardiopulmonary bypass: a pilot investigation on the effects of a half-dose aprotinin protocol on postoperative blood loss and hemostatic activation and inflammatory response.

Koster et al describe the use of a half-dose aprotinin protocol and the influence on postoperative blood loss. The second endpoint of this investigation was a bunch of several hemostatic and inflammatory markers. The authors claim to apply a new heparin-level-based anticoagulation management. Not surprisingly, the authors found a significant reduction of postop bleeding tendency. […]