Preoperative use of enoxaparin increases the risk of postoperative bleeding and re-exploration in cardiac surgery patients.
Interesting and important article; certainly of interest for practicing physicians. – Marcel Levi
Tag: bleeding
Recombinant activated factor VII (NovoSeven): addition to replacement therapy in acute, uncontrolled and life-threatening bleeding.
Over the last seven years there has been increasing number of case reports and studies documenting the effectiveness and safety of using rFVIIa (NovoSeven) in treating non-hemophiliac patients with severe […]
Antidotes to haemorrhage: recombinant factor VIIa.
This is an excellent and comprehensive review on the use of rFVIIa, its mechanism of action and various indications for its use in controlling bleeding in congenital and acquired coagulation […]
The effects of a polymerized bovine-derived hemoglobin solution in a rabbit model of arterial thrombosis and bleeding.
Using a well recognized experimental model, the authors demonstrated that polymerized bovine-based hemoglobin solution markedly reduced arterial thrombosis rate and increased bleeding time in rabbits. These results are in contrast […]
An assessment of the management of acute bleeding varices: a multicenter prospective member-based study.
The survey gives a good and very detailed overview about cause and current management of acute bleeding varices including rebleeding and lethality. However, no data except the amount of blood […]
Improved hemostasis with superactive analogs of factor VIIa in a mouse model of hemophilia A.
This is an elegant paper which studied the hemostatic efficacy of different doses of rFVIIa and three of its analogs on controlling bleeding in mice with antibody induced hemophilia. There […]
Increased local procoagulant action: a mechanism contributing to the favorable hemostatic effect of recombinant FVIIa in PLT disorders.
This paper reports the procoagulant effect of rFVIIa in experimental thrombocytopenia, and in thromboasthenic platelets due to natural or experimentally induced glycoprotein deficiency. It shows that rFVIIa improved fibrin deposition, […]
The use of recombinant factor VIIa in children with inherited platelet function disorders.
This is an interesting report on a small series of children with inherited platelet dysfunction treated with rFVIIa for acute bleeding or preoperatively. Response seemed to correlate with type of […]
Effect of recombinant activated factor VII on perioperative blood loss in patients undergoing retropubic prostatectomy: a double-blind placebo-controlled randomised trial.
This is an interesting and important controlled study on using rFVIIa electively in the beginning of major surgery to reduce blood loss and blood transfusion. Patients were divided into three […]
Treatment of critical bleeding in the future intensive care unit. [Editorial]
Uncontrolled bleeding remains a major problem in intensive care and emergency medicine which still requires effective and innovative treatment options. This editorial highlights that there is growing evidence on the […]
Recombinant factor VIIa after aortic valve replacement in a patient with osteogenesis imperfecta.
This is another case report on the efficacy of Novoseven in controlling severe bleeding in cardiac surgery. Post-operative bleeding continued in spite of the use of blood products and aprotinin […]
Case report on recombinant coagulation factor VIIa in the treatment of three haemophilia A patients with inhibitors in Singapore.
This is a first case report on using rFVIIa (Novoseven) to treat hemophilia patients with high response inhibitors to factor VIII in Singapore. The patients had bleeding with moderate severity, […]
Influence of a new hydroxyethylstarch preparation (HES 130/ 0.4) on coagulation in cardiac surgical patients.
Note that volumes of Gelatine and Starch required to maintain CVP are no different between two groups, suggesting that the two solutions are equally effective as plasma volume expanders. However, […]
