The effects of a polymerized bovine-derived hemoglobin solution in a rabbit model of arterial thrombosis and bleeding.
Using a well recognized experimental model, the authors demonstrated that polymerized bovine-based hemoglobin solution markedly reduced arterial thrombosis rate and increased bleeding time in rabbits. These results are in contrast with those reported with other hemoglobin-based oxygen carriers. There is increasing evidence that the effects of hemoglobin solutions on hemostasis can be influenced by their […]
This review article describes the nine different hemoglobin-based oxygen carriers that have been developed since the 1980s. Seven of them are currently being tested in phase II or phase III clinical trials. – Philippe Van der Linden A general, potentially useful, text on hemoglobin-based oxygen carriers for clinicians. Specific molecules are reviewed somewhat briefly. – […]
Effects of ultra-purified polymerized bovine hemoglobin on local tissue oxygen tension in striated skin muscle – An efficacy study in the hamster.
This is another study on the potential benefits of an oxygen carrier (ultrapurified polymerized bovine hemoglobin solution) on tissue perfusion after hypervolemic infusion or exchange transfusion of 50% of blood volume in a hamster model. The authors have shown that the infusion of the hemoglobin solution actually decreases (slightly) mean tissue pO2 but homogenizes local […]
Oxygen transport dynamics of acellular hemoglobin solutions in an isovolemic hemodilution model in swine.
It does not come as a surprise that hemoglobin solutions improve oxygen delivery and consumption in severely anemic swine. However, changes in P-50 do not appear to modify oxygen dynamics over a large range of hematocrits. This is quite a surprise, considering the efforts taken by the manufacturers to produce a solution that possess the […]
Hemoglobin-vesicles as oxygen carriers – Influence on phagocytic activity and histopathological changes in reticuloendothelial system.
A good basic science article demonstrating that a single dose of hemoglobin encapsulated in a phospholipid bilayer membrane injected in rats has a transient and acceptable effect on the reticuloendothelial system. Initially, the RES is depressed but function returns to normal as hemoglobin vesicles are cleared. Questions that remain relate to the effect of hemoglobin […]