The effects of a polymerized bovine-derived hemoglobin solution in a rabbit model of arterial thrombosis and bleeding.
Using a well recognized experimental model, the authors demonstrated that polymerized bovine-based hemoglobin solution markedly reduced arterial thrombosis rate and increased bleeding time in rabbits. These results are in contrast […]
Hemoglobin-based oxygen carriers.
This review article describes the nine different hemoglobin-based oxygen carriers that have been developed since the 1980s. Seven of them are currently being tested in phase II or phase III […]
Effects of ultra-purified polymerized bovine hemoglobin on local tissue oxygen tension in striated skin muscle – An efficacy study in the hamster.
This is another study on the potential benefits of an oxygen carrier (ultrapurified polymerized bovine hemoglobin solution) on tissue perfusion after hypervolemic infusion or exchange transfusion of 50% of blood […]
Oxygen transport dynamics of acellular hemoglobin solutions in an isovolemic hemodilution model in swine.
It does not come as a surprise that hemoglobin solutions improve oxygen delivery and consumption in severely anemic swine. However, changes in P-50 do not appear to modify oxygen dynamics […]
Hemoglobin-vesicles as oxygen carriers – Influence on phagocytic activity and histopathological changes in reticuloendothelial system.
A good basic science article demonstrating that a single dose of hemoglobin encapsulated in a phospholipid bilayer membrane injected in rats has a transient and acceptable effect on the reticuloendothelial […]