This experimental study investigated the effects of oxygen-carrying and non-oxygen-carrying heme solutions on the induction of the protective enzyme heme oxygenase (HO)-1 in a rat model of hemorrhagic shock (fixed […]
This experimental study, using quite sophisticated methods, demonstrates that a perfluorocarbon emulsion together with a high FiO2 is able to improve oxygen availability to the liver as compared to stored […]
The authors investigated, in a multicenter, double-blind, randomized trial, whether diaspirin-crosslinked hemoglobin (DCLHb) could reduce the use of allogeneic blood transfusions. This is a very interesting study for several reasons. […]
This article reviews the current status of the hemoglobin-based oxygen carriers (HBOC) presently under development. It also introduces the idea that all the HBOCs are not expected to be clinically […]
This experimental observational study reports that, in anesthetized pigs undergoing hemorrhage, small volume resuscitation (6 mL/kg) of a bovine hemoglobin based oxygen carrier can restore mean arterial pressure and cardiac […]
This review article discusses the past, present and future of oxygen carriers, not only as “blood substitutes” but also, more importantly, as “oxygen therapeutics.” – Philippe Van der Linden
This is another study on the potential benefits of an oxygen carrier (ultrapurified polymerized bovine hemoglobin solution) on tissue perfusion after hypervolemic infusion or exchange transfusion of 50% of blood […]
It does not come as a surprise that hemoglobin solutions improve oxygen delivery and consumption in severely anemic swine. However, changes in P-50 do not appear to modify oxygen dynamics […]
The important message in this case is that a hemoglobin-based oxygen carrier was able to restore viable cardiovascular function after exsanguinating cardiac arrest in a swine model of liver injury […]
Interesting article evaluating the place of a hemoglobin-based oxygen-carrying solution in the resuscitation of severe hemorrhagic shock. – P. Van der Linden.
NATA: Network for the advancement of Patient Blood Management, Haemostasis and Thrombosis
MISSION: Providing a multidisciplinary forum for dialogue between haematologists, transfusion medicine specialists, anaesthesiologists, intensive care and emergency physicians, surgeons, perfusionists, nurses, biomedical scientists and ther healthcare professionals.
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