Patient safety and blood transfusion: new solutions.
Interesting paper on new solutions for making transfusions safer. The only aspect which is missing is a better education of the staff involved in hemotherapy, which is even more important […]
Tag: BLOOD
Perflubron emulsion in prolonged hemorrhagic shock: influence on hepatocellular energy metabolism and oxygen-dependent gene expression.
This experimental study, using quite sophisticated methods, demonstrates that a perfluorocarbon emulsion together with a high FiO2 is able to improve oxygen availability to the liver as compared to stored […]
A mathematical model of cell salvage efficiency.
In this excellent paper, the authors develop a mathematical model that may help our understanding of the efficiency of blood salvage. The basic insights from these theoretical considerations are that […]
Recombinant human transgenic antithrombin in cardiac surgery: a dose-finding study.
This is a very important paper in two ways. First, it highlights ongoing activation of hemostasis in the postoperative period as demonstrated by the control group. The scale of Figure […]
Platelet transfusions in children: results of a randomized, prospective, crossover trial of plasma removal and a prospective audit of WBC reduction.
Disappointing and rather surprising results. The lower incidence of transfusion reactions (TR) in children is not surprising since the referred frequency of TR in adults (up to 37% from literature) […]
Clinical significance of RBC alloantibodies and autoantibodies in sickle cell patients who received transfusions.
The study shows that transfusion of blood matched for Rh and Kell systems would reduce alloimmunization to 27% and reduce delayed hemolytic transfusion reaction, but would not prevent it. Delayed […]
Are lactated Ringer’s solution and normal saline solution equal with regard to coagulation?
This study compares the perioperative effects of a saline crystalloid and a more balanced and buffered electrolyte crystalloid on clotting. The differences thought to be related to blood clotting that […]
A double-blind study to evaluate the safety of recombinant human hemoglobin in surgical patients during general anesthesia.
The authors evaluated the safety profile of escalating doses of rHb1.1 in patients undergoing surgery under general anesthesia. The adverse effects observed (and the authors’ conclusions) are those that one […]
Amplification of the DNA polymerase I gene of Treponema pallidum from whole blood of persons with syphilis.
The article confirms by means of the sensitive PCR technique that Treponema pallidum may be found in blood during the whole course of syphilis infection. – V. Kretschmer.
The effects of hemoglobin glutamer-200 (Bovine) on the microcirculation in a canine hypovolemia model: A noninvasive computer-assisted intravital microscopy study.
The authors present a dog model of hemorrhage (similar to 40% blood loss) that will be useful for the evaluation of treatment(s) of severe hypovolemia. In this case, hemoglobin glutamer-200 […]
Prospective RBC phenotype matching in a stroke-prevention trial in sickle cell anemia: a multicenter transfusion trial.
For a transfusionist from West/North Europe, the results are predictable and the conclusion expectable. In Germany, the prospective RBC phenotype matching in sickle cell anemia and thalassemia, and even in […]
High intensity focused ultrasound: A method of hemostasis.
This inovative work bears watching. Potential applications include minimally invasive, i.e., laparoscopic, approaches to control of traumatic liver injury. – R. K. Spence.
