Off-label use of recombinant factor VIIA concentrates after cardiac surgery.
This article reviews the mechanism of action of rFVIIa and outlines its off-label use in management of perioperative bleeding and intracranial hemorrhage. Authors review the paper of Raivio et al […]
Recombinant factor VIIa in the treatment of postoperative hemorrhage after cardiac surgery.
This is one center experience on the use of rFVIIa to treat severe postoperative bleeding following cardiac surgery after failure of conventional therapy with blood components and hemostatic agents. Bleeding […]
Successful use of one dose of recombinant factor VIIa to control severe bleeding after emergency aortic arch replacement in deep hypothermic circulatory arrest.
This is a single case report on the effectiveness of rFVIIa in controlling severe postoperative bleeding following repair of aortic artery dissection under conditions of cardiopulmonary bypass and deep hypothermic […]
Recombinant factor VIIa for life-threatening bleeding in high-risk cardiac surgery despite full-dose aprotinin.
This is a case report on using rFVIIa to control severe bleeding following orthotopic cardiac transplant with multiple previous cardiac surgeries. Bleeding was initially uncontrolled despite the use of continuous […]
Heparin-level-based anticoagulation management during cardiopulmonary bypass: a pilot investigation on the effects of a half-dose aprotinin protocol on postoperative blood loss and hemostatic activation and inflammatory response.
Koster et al describe the use of a half-dose aprotinin protocol and the influence on postoperative blood loss. The second endpoint of this investigation was a bunch of several hemostatic […]
The association of lowest hematocrit during cardiopulmonary bypass with acute renal injury after coronary artery bypass surgery.
Challenging data about correlation between hemodilution and acute renal injury (documented by increase of creatinine), however, seems only to be relevant in patients with overweight. – Volker Kretschmer
Factors affecting transfusion of fresh frozen plasma, platelets, and red blood cells during elective coronary artery bypass graft surgery.
Important study on factors influencing requirements on blood components during coronary artery bypass graft surgery. More than 80 preop. multidimensional risk variables were evaluated. Effective predictors of blood need were […]
Does priming implementation with low-dose albumin reduce postoperative bleeding following cardiopulmonary bypass?
Concludes that addition of Albumin to crystalloid prime reduces bleeding following cardiac by-pass surgery. At first glance looks like a big study (n=154 with crystalloid and low dose 20% albumin […]
Blood use in patients undergoing coronary artery bypass surgery: impact of cardiopulmonary bypass pump, hematocrit, gender, age, and body weight.
Important analysis of factors influencing blood transfusion requirement, however without new aspects. – Volker Kretschmer
Use of perflubron emulsion to decrease allogeneic blood transfusion in high-blood-loss non-cardiac surgery: results of a European phase 3 study.
The authors should be commended for carrying out an elaborate multicenter study in such an elegant fashion. The Methods are well described, the statistics appropriate and the Results are presented […]
Autologous blood sequestration using a double venous reservoir bypass circuit and polymerized hemoglobin prime.
This experimental study describes a modified cardiopulmonary bypass circuit using a bovine hemoglobin solution priming that protects a portion of the autologous blood volume from the damaging effects of bypass. […]
Intraoperative low-volume acute normovolemic hemodilution in adult open-heart surgery.
In this prospective randomized study, intraoperative acute isovolemic hemodilution (ANH) was not associated with a reduction in the need for allogeneic blood transfusion. However, this study evaluated the contribution of […]
Retrograde autologous priming of the cardiopulmonary bypass circuit reduces blood transfusion after coronary artery surgery.
This article confirms previous studies showing that a reduction of the bypass circuit priming volume can be associated with a reduction in allogeneic blood use. This beneficial effect is related […]
Are lactated Ringer’s solution and normal saline solution equal with regard to coagulation?
This study compares the perioperative effects of a saline crystalloid and a more balanced and buffered electrolyte crystalloid on clotting. The differences thought to be related to blood clotting that […]
Aprotinin in orthotopic liver transplantation: Evidence for a prohemostatic, but not a prothrombotic, effect.
This study supports the hypothesis that aprotinin is an anticoagulant which prolongs the aPTT and has no or marginal risks of thromboembolic complications. – Wulf Dietrich.