Absence of beneficial effect of acute normovolemic hemodilution combined with aprotinin on allogeneic blood transfusion requirements in cardiac surgery.

This prospective randomized study showed that acute normovolemic hemodilution (ANH) did not reduce the risk of allogeneic blood transfusion in elective cardiac surgical patients. However, the interpretation of these results is limited by the fact that ANH was not performed in clinical conditions where its efficacy can be demonstrated: low blood volume collection and reduced […]

Heparin coating of the extracorporeal circuit combined with leukocyte filtration reduces coagulation activity, blood loss and blood product substitution.

Heparin bonded circuits have become standard in extracorporeal bypass circuits for open heart surgery. Leukoreduction of allogeneic red blood cells is also considered a standard of care in many countries. Martens and colleagues concluded from this small series of patients that the addition of a leukocyte filter to the heparin bonded circuit is associated with […]