Acute coagulopathy after reperfusion of the liver graft in children correction with recombinant activated factor VII.
This pediatric organ transplant team from Poland reports effective use of rFVIIa in 40 patients immediately before liver transplant surgery, and is reporting efficacy in 7 children presenting with severe […]
Possible role of recombinant activated factor VII (RFVIIa) in the control of hemorrhage associated with massive trauma.
This is a report on the largest series on the use of rFVIIa in treating patients suffering from uncontrolled bleeding as a result of trauma in spite of surgical treatment […]
A novel hemostatic agent: the potential role of recombinant activated factor VII (RFVIIa) in anesthetic practice.
This is an excellent literature review on the adjuvant use of rFVIIa in treating severe bleeding associated with surgical procedures in non-hemophiliac patients. It gives an overview of the mechanism […]
The effect of recombinant factor VIIa on coagulopathic pigs with grade V liver injuries.
This study illustrates one of the unusual situations in Medicine where evidence of drug efficacy in human preceded animal studies. After the publication of several case reports on the effectiveness […]
Successful outcome of a cirrhotic patient with postoperative haematuria treated with a single high dose of recombinant factor VIIa.
Etiology of bleeding in patients with liver disease is multifactorial, and there has been variable response to treatment with rFVIIa, although correction of prolonged prothrombin time in such patients has […]