Large-dose hydroxyethyl starch 130/0.4 does not increase blood loss and transfusion requirements in coronary artery bypass surgery compared with hydroxyethyl starch 200/0.5 at recommended doses.
This is one of the largest PRCTs of colloid vs. colloid to date. It forms the basis of the new European dose limit for HES 130/0.4 at 50 mL/kg. Trials over 100 patients, with a power calculation and at least some attempt at blinding are a rare treat. The discussion is balanced and refreshing in […]
Comparison of the effects of a 50% exchange-transfusion with albumin, hetastarch, and modified hemoglobin solutions.
This preliminary (considering phase III studies have been completed or are underway) study in rats adds little to what has already been published on this issue in more elaborate animal models. While interesting, the study falls short of answering the true question: do hemoglobin solutions such as o-raffinose-crosslinked hemoglobin improve outcome in humans? – J.-F. […]