A less invasive treatment strategy to prevent intracranial hemorrhage in fetal and neonatal alloimmune thrombocytopenia.
Immunoglobulin therapy in pregnant women with antibodies against platelet antigens of the fetus and neonetal alloimmune thrombocytopenia in the previous child proved successful. This study, which was not controlled or randomized, showed at least no disadvantage of a less invasive treatment strategy omitting regular fetal blood sampling and intra-uterine platelet transfusion. – V. Kretschmer.
The article gives a good overview about incidence, pathogenesis, clinical symptoms, clinical course, diagnostics, therapy and prognosis of fetal parvovirus B19 infection by analysis of literature. The prognosis is mainly determined by the anemia. Data suggest a benefit of transfusion therapy. – V. Kretschmer.