Blood substitutes: the future is now.
Review articles are interesting but, unfortunately, do not add to existing knowledge. They can be more or less well documented and interesting for clinicians. The profusion of review articles on […]
Small-volume resuscitation with HBOC-201: effects on cardiovascular parameters and brain tissue oxygen tension in an out-of-hospital model of hemorrhage in swine.
This experimental observational study reports that, in anesthetized pigs undergoing hemorrhage, small volume resuscitation (6 mL/kg) of a bovine hemoglobin based oxygen carrier can restore mean arterial pressure and cardiac […]
Hemoglobin-based oxygen carriers.
This review article describes the nine different hemoglobin-based oxygen carriers that have been developed since the 1980s. Seven of them are currently being tested in phase II or phase III […]
Effects of ultra-purified polymerized bovine hemoglobin on local tissue oxygen tension in striated skin muscle – An efficacy study in the hamster.
This is another study on the potential benefits of an oxygen carrier (ultrapurified polymerized bovine hemoglobin solution) on tissue perfusion after hypervolemic infusion or exchange transfusion of 50% of blood […]
Influence of cell-free Hb on local tissue perfusion and oxygenation in acute anemia after isovolemic hemodilution.
This experimental study shows that, in hamsters, exchange transfusion with polymerized bovine hemoglobin to a hemoglobin content of 6.7 g/dL failed to maintain tissue oxygenation and in-vivo functional capillary density […]
A double-blind study to evaluate the safety of recombinant human hemoglobin in surgical patients during general anesthesia.
The authors evaluated the safety profile of escalating doses of rHb1.1 in patients undergoing surgery under general anesthesia. The adverse effects observed (and the authors’ conclusions) are those that one […]