In this observational study, the authors report their experience with the use of acute normovolemic hemodilution in cardiac surgery patients. – Philippe Van der Linden This article convincingly shows that ANH in patients undergoing cardiac surgery significantly reduces the need for allogeneic blood transfusion. Autologous blood removed ranged from 1 (70%) to 2-5 (30% of […]
This is an interesting and new case report on the occurrence of acquired factor VII deficiency in eight patients following intensive chemotherapy and/or radiotherapy followed by hematopoietic stem cell transplantation (SCT), associated with serious and sometimes fatal hemorrhagic complications with poor response to transfusion of blood components. Tests for antibodies against FVII were negative. It […]
Clinical significance of RBC alloantibodies and autoantibodies in sickle cell patients who received transfusions.
The study shows that transfusion of blood matched for Rh and Kell systems would reduce alloimmunization to 27% and reduce delayed hemolytic transfusion reaction, but would not prevent it. Delayed hemolytic transfusion reactions were mild and did not cause hyperhemolysis in sickle cell patients. However, the cause of hyperhemolysis, which is a severe problem, was […]
This study raises two important questions: First, are the observed adverse events upon high dose iron dextran users due to confounding variables such as comorbidity, or are they true iron dextran effects? Second, if they are true iron dextran effects, are they caused by the iron or the dextran? – C. Gasche.
Prospective RBC phenotype matching in a stroke-prevention trial in sickle cell anemia: a multicenter transfusion trial.
For a transfusionist from West/North Europe, the results are predictable and the conclusion expectable. In Germany, the prospective RBC phenotype matching in sickle cell anemia and thalassemia, and even in patients with chronic anemia, has been performed for many years (at least for C, c, E, e, K) and does not pose major problems. It […]