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The use of acute normovolemic hemodilution in patients undergoing cardiac surgery.

In this observational study, the authors report their experience with the use of acute normovolemic hemodilution in cardiac surgery patients. – Philippe Van der Linden This article convincingly shows that ANH in patients undergoing cardiac surgery significantly reduces the need for allogeneic blood transfusion. Autologous blood removed ranged from 1 (70%) to 2-5 (30% of […]

Acquired factor VII deficiency in hematopoietic stem cell transplant recipients.

This is an interesting and new case report on the occurrence of acquired factor VII deficiency in eight patients following intensive chemotherapy and/or radiotherapy followed by hematopoietic stem cell transplantation (SCT), associated with serious and sometimes fatal hemorrhagic complications with poor response to transfusion of blood components. Tests for antibodies against FVII were negative. It […]

Iron administration and clinical outcomes in hemodialysis patients.

This study raises two important questions: First, are the observed adverse events upon high dose iron dextran users due to confounding variables such as comorbidity, or are they true iron dextran effects? Second, if they are true iron dextran effects, are they caused by the iron or the dextran? – C. Gasche.