Preoperative acute normovolemic hemodilution: a meta-analysis.
This meta-analysis reviewed 42 trials evaluating the efficacy and safety of preoperative acute normovolemic hemodilution (ANH). The authors reported that the risk of allogeneic transfusion was similar among patients receiving […]
The use of recombinant factor VIIa in children with inherited platelet function disorders.
This is an interesting report on a small series of children with inherited platelet dysfunction treated with rFVIIa for acute bleeding or preoperatively. Response seemed to correlate with type of […]
Effectiveness of acute normovolemic hemodilution to minimize allogeneic blood transfusion in major liver resections.
In this randomized controlled trial, acute normovolemic hemodilution (ANH) resulted in a decrease of allogeneic blood exposure in ASA I-II patients undergoing major liver resection. As emphasized by Dr. Weiskopf […]
Experience with use of recombinant activated factor VII.
This is a case report of successfully treating hemorrhage with rFVIIa in four patients with factor VIII and one with factor V inhibitor. One patient was initially treated with APCC […]
Comparison of the effects of a 50% exchange-transfusion with albumin, hetastarch, and modified hemoglobin solutions.
This preliminary (considering phase III studies have been completed or are underway) study in rats adds little to what has already been published on this issue in more elaborate animal […]
Oxygen transport dynamics of acellular hemoglobin solutions in an isovolemic hemodilution model in swine.
It does not come as a surprise that hemoglobin solutions improve oxygen delivery and consumption in severely anemic swine. However, changes in P-50 do not appear to modify oxygen dynamics […]
New products for managing inhibitors to coagulation factors: a focus on recombinant factor VIIa concentrate.
A very good review of inhibitors to coagulation factors, in congenital or acquired hemophilia, that covers the incidence, pathogenesis, treatment strategies (including different alternatives to human factors), and induction of […]