A randomized comparison of every-2-week darbepoetin alfa and weekly epoetin alfa for the treatment of chemotherapy-induced anemia in patients with breast, lung, or gynecologic cancer.
An important trial by Schwartzberg et al. has recently been published in The Oncologist. In prospective manner, this trial tested the two erythropoietin preparations commonly used in the US, epoetin […]
Effect of recombinant human erythropoietin on quality of life in cancer patients receiving chemotherapy: Results of a randomized, controlled trial.
A nice demonstration again in a placebo controlled trial that recombinant EPO is safe and effective in anemic cancer patients on chemorx. The three times weekly dose is more commonly […]
Efficacy and safety of darbepoetin alfa in anaemic patients with lymphoproliferative malignancies: a randomized, double-blind, placebo-controlled study.
A nicely done placebo controlled trial of darbepoetin in anemic hematologic malignancy patients demonstrating darbepoetin’s efficacy and safety. – David H. Henry
Once-weekly epoetin beta is highly effective in treating anaemic patients with lymphoproliferative malignancy and defective endogenous erythropoietin production.
This is an important EPO trial in hematologic malignancy patients for two reasons. It demonstrates that lower EPO levels predict response… an observation not reproduced in solid tumor patients but […]
The effects of epoetin alfa on transfusion requirements in head and neck cancer patients: a prospective, randomized, placebo-controlled study.
An exciting issue is studied in this head/neck cancer patient population. Perioperative EPO may have a role to decrease blood transfusion needs and speed recovery. While this is only a […]
Transfusion in premature infants impairs production and/or release of red blood cells, white blood cells and platelets.
The author concludes that suppression of erythro-, leuko- and thrombopoiesis within 48 hours after transfusion decreases the amount of precursor cells in the peripheral blood. This is a very important […]
The theory and practice of bloodless surgery.
A very thorough overview of all aspects of blood-sparing methods. – V. Kretschmer
Efficacy of a low-dose intravenous iron sucrose regimen in peritoneal dialysis patients.
The authors evaluated a low dose iron substitution scheme for the effectiveness in patients with peritoneal dialysis: 50 mg iron sucrose every other week is effective in patients with ferritin […]
Iron administration and clinical outcomes in hemodialysis patients.
This study raises two important questions: First, are the observed adverse events upon high dose iron dextran users due to confounding variables such as comorbidity, or are they true iron […]
The effect of i.v. iron alone or in combination with low- dose erythropoietin in the rapid correction of anemia of chronic renal failure in the predialysis period.
This is a most valuable study concerning the use of rHuEPO and iron sucrose in predialysis patients. While it is quite predictable that rHuEPO and iron patients show a faster […]
Considerations for optimal iron use for anemia due to chronic kidney disease.
It is certainly of great value to have an overview about different iron regimens in combination with rHuEPO. However, at least in Europe, there is common agreement that parenteral iron […]
Outcome of infants receiving in-utero transfusions for haemolytic disease.
Retrospective analysis of infants receiving in-utero transfusion showing good outcome. No information about immunohematological methods used. There was a trend of less exchange transfusions in infants having more in-utero transfusions. […]