Possible role of recombinant activated factor VII (RFVIIa) in the control of hemorrhage associated with massive trauma.
This is a report on the largest series on the use of rFVIIa in treating patients suffering from uncontrolled bleeding as a result of trauma in spite of surgical treatment […]
Approaches to successful total knee arthroplasty in haemophilia A patients with inhibitors.
Three cases of hemophilia A with inhibitors to factor VIII underwent total knee arthroplasty (TKA) using rFVIIa in the first patient, rFVIIa and high dose rFVIII in the second and […]
Orthopaedic surgery in haemophilic patients with inhibitors: an overview.
This is an excellent review on a large series reporting the use of rFVIIa in orthopedic surgeries in patients with hemophilia A and B with inhibitors, in addition to a […]
Continuous infusion of coagulation factor products.
This is an interesting review on the use of continuous infusion of coagulation factor products over the last 11 years. It concludes that effects were favorable in comparison to intermittent […]
Rationale for the use of high dose rFVIIa in a high-titre inhibitor patient with haemophilia B during major orthopaedic procedures.
This is a case report of a child with severe hemophilia B and high titer factor IX inhibitor who was not achieving good hemostasis on conventional doses of rFVIIa. Pharmacokinetic […]
Development of an animal model for assessment of the hemostatic efficacy of fibrin sealant in vascular surgery.
Having a sound and reproducible animal model to test the value of an existing therapy beyond its initial application is certainly a step forward. Kheirabadi and associates have taken this […]