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Effect of intraoperative fluid management on outcome after intraabdominal surgery.

Another randomized controlled trial demonstrating that the recipe book administration of larger quantities of crystalloid (i.e., 12 ml/kg/hr irresepective of hemodynamics) around the time of major surgery is associated with a worse outcome. Note that the patients in the “restricted group” receive a lower hourly rate (4 ml/kg/hr) plus targeted fluid boluses (of Lactated Ringer’s) […]

HBOC-201 improves survival in a swine model of hemorrhagic shock and liver injury.

This experimental study highlights the potential beneficial therapeutic effect of a hemoglobin-based oxygen carrier (HBOC) used as a resuscitation fluid during severe traumatic shock. In contrast to colloid (high molecular weight hydroxyethyl starch) based resuscitation, a similar volume of HBOC from bovine origin prevented exsanguination cardiac arrest, allowing for significantly higher long term (96 hr) […]