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Normovolemic hemodilution with Hb vesicle solution attenuates hypoxia in ischemic hamster flap tissue.

Encapsulation of human hemoglobin in liposome vesicles represents a useful method to attenuate the vasoactivity observed with conjugated or polymerized hemoglobin solutions currently under experimental and clinical investigation. Another advantage of hemoglobin vesicles is that oxygen affinity of the solution can be adapted by modifying the amount of coencapsulated pyridoxal 5′-phosphate, an allosteric effector. In […]

Improved oxygenation in ischemic hamster flap tissue is correlated with increasing hemodilution with Hb vesicles and their O2 affinity.

Encapsulation of human hemoglobin in liposome vesicles represents a useful method to attenuate the vasoactivity observed with conjugated or polymerized hemoglobin solutions currently under experimental and clinical investigation. Another advantage of hemoglobin vesicles is that oxygen affinity of the solution can be adapted by modifying the amount of coencapsulated pyridoxal 5′-phosphate, an allosteric effector. In […]