Beta-adrenergic stimulation restores, oxygen extraction reserve during acute normovolemic hemodilution.
This experimental study demonstrates that the blunting of the cardiac output response to acute normovolemic hemodilution during anesthesia can be reversed by the administration of a beta-adrenergic drug. – Philippe […]
Oxygen transport dynamics of acellular hemoglobin solutions in an isovolemic hemodilution model in swine.
It does not come as a surprise that hemoglobin solutions improve oxygen delivery and consumption in severely anemic swine. However, changes in P-50 do not appear to modify oxygen dynamics […]
Acute hemodilution in a chronic polycythemic patient may be deleterious.
This case report showed that chronic polycythemia could be associated with peripheral shunting that might reduce patient’s tolerance to acute isovolemic hemodilution. – P. Van der Linden. The authors have […]
Influence of cell-free Hb on local tissue perfusion and oxygenation in acute anemia after isovolemic hemodilution.
This experimental study shows that, in hamsters, exchange transfusion with polymerized bovine hemoglobin to a hemoglobin content of 6.7 g/dL failed to maintain tissue oxygenation and in-vivo functional capillary density […]
Hypotensive resuscitation using a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201) leads to reversal of anaerobic metabolism.
Interesting article evaluating the place of a hemoglobin-based oxygen-carrying solution in the resuscitation of severe hemorrhagic shock. – P. Van der Linden.