Diaspirin-crosslinked hemoglobin reduces blood transfusion in noncardiac surgery: a multicenter, randomized, controlled, double-blinded trial.

The authors investigated, in a multicenter, double-blind, randomized trial, whether diaspirin-crosslinked hemoglobin (DCLHb) could reduce the use of allogeneic blood transfusions. This is a very interesting study for several reasons. First, the study is one of the very few in the area of transfusion medicine that was able to implement and maintain a double-blind study […]

Polymerized bovine hemoglobin solution as a replacement for allogeneic red blood cell transfusion after cardiac surgery: results of a randomized, double-blind trial.

The article by Jerrold Levy et al. is one of the few randomized controlled trials published on the use of hemoglobin-based oxygen-carrying (HBOC) solutions in patients. Similarly to the study by Lamy et al. on the use of diaspirin cross-linked hemoglobin published in Anesthesiology in 2000, HBOC-201 was used for the initial treatment of anemia […]

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