Challenging review that discusses optimal hemoglobin level in regard to postoperative rehabilitation, and therefore indirectly questions restrictive hemoglobin thresholds for transfusion. – Volker Kretschmer
Our comments were published in a letter to the Editor (see Hardy JF, Belisle S, Van der Linden P. Combined blood substitute and eryth-ropoietin therapy in a severely injured Jehovah’s witness. N Engl J Med 2002;347(9):696- 697). It is interesting to note that the rise in hemoglobin concentration reported in this patient with high-dose erythropoietin […]
Oxygen transport dynamics of acellular hemoglobin solutions in an isovolemic hemodilution model in swine.
It does not come as a surprise that hemoglobin solutions improve oxygen delivery and consumption in severely anemic swine. However, changes in P-50 do not appear to modify oxygen dynamics over a large range of hematocrits. This is quite a surprise, considering the efforts taken by the manufacturers to produce a solution that possess the […]
A double-blind study to evaluate the safety of recombinant human hemoglobin in surgical patients during general anesthesia.
The authors evaluated the safety profile of escalating doses of rHb1.1 in patients undergoing surgery under general anesthesia. The adverse effects observed (and the authors’ conclusions) are those that one would expect for this type of product. Unfortunately, it appears that we have not yet found the Holy Grail of hemoglobin replacement therapy… – J.-F. […]
Prospective RBC phenotype matching in a stroke-prevention trial in sickle cell anemia: a multicenter transfusion trial.
For a transfusionist from West/North Europe, the results are predictable and the conclusion expectable. In Germany, the prospective RBC phenotype matching in sickle cell anemia and thalassemia, and even in patients with chronic anemia, has been performed for many years (at least for C, c, E, e, K) and does not pose major problems. It […]