The use of rFVIIa in conditions associated with disseminated intravascular coagulation (DIC) has always been an area of concern in view of the theoretical possibility of enhancing thrombotic complications. However, […]
This is a comprehensive update review on the various indications for the use of rFVIIa in both hemophilic and nonhemophilic patients, reviewing the major published work in these areas.
Over the last seven years there has been increasing number of case reports and studies documenting the effectiveness and safety of using rFVIIa (NovoSeven) in treating non-hemophiliac patients with severe […]
This is an excellent literature review on the adjuvant use of rFVIIa in treating severe bleeding associated with surgical procedures in non-hemophiliac patients. It gives an overview of the mechanism […]
This experimental observational study reports that, in anesthetized pigs undergoing hemorrhage, small volume resuscitation (6 mL/kg) of a bovine hemoglobin based oxygen carrier can restore mean arterial pressure and cardiac […]
This experimental study highlights the potential beneficial therapeutic effect of a hemoglobin-based oxygen carrier (HBOC) used as a resuscitation fluid during severe traumatic shock. In contrast to colloid (high molecular […]
This is a case report of two female patients with severe vaginal bleeding following previous treatment of gynecological malignancies and no pre-existing coagulation factor deficiency. Bleeding was controlled with two […]
Uncontrolled bleeding remains a major problem in intensive care and emergency medicine which still requires effective and innovative treatment options. This editorial highlights that there is growing evidence on the […]
Management of bleeding in patients who refuse blood transfusion may prove to be a therapeutic challenge, and therefore blood sparing modes of therapy need to be considered. In severe surgical […]
This is a very good review on the use and mechanism of action of rFVIIa in acquired hemophilia. It reviews the physiological coagulation pathway and the central role of factor […]
This paper reviews the existing evidence supporting the efficacy and safety of rFVIIa in treating bleeding manifestations in patients with thrombocytopenia or those with excessive anticoagulation with warfarin. Currently this […]
This study illustrates one of the unusual situations in Medicine where evidence of drug efficacy in human preceded animal studies. After the publication of several case reports on the effectiveness […]
This is an interesting case report on the use of rFVIIa in treating uncontrollable surgical bleeding in a patient not known to have a pre-existing coagulopathy. The patient had a […]
This is an interesting and new case report on the occurrence of acquired factor VII deficiency in eight patients following intensive chemotherapy and/or radiotherapy followed by hematopoietic stem cell transplantation […]
A useful study (notwithstanding power) and review of current practices. – F. Regan and M. Contreras.
NATA: Network for the advancement of Patient Blood Management, Haemostasis and Thrombosis
MISSION: Providing a multidisciplinary forum for dialogue between haematologists, transfusion medicine specialists, anaesthesiologists, intensive care and emergency physicians, surgeons, perfusionists, nurses, biomedical scientists and ther healthcare professionals.
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