This is an interesting report on a small series of children with inherited platelet dysfunction treated with rFVIIa for acute bleeding or preoperatively. Response seemed to correlate with type of […]
This is a clearly written article detailing the mechanism of action of rFVIIa and its interaction with tissue factor and platelets leading to its hemostatic effect in hemophilia patients with […]
This is another case report on the use of rFVIIa in controlling excessive bleeding during open heart surgery. A 57 year old woman underwent implantation of bilateral ventricular assist device […]
This is a case report on a successful use of recombinant factor VIIa in treating hematemesis in an 11-month-old infant who suffered with esophageal varices, hepatic dysfunction and previous necrotizing […]
This is another case report on the efficacy of Novoseven in controlling severe bleeding in cardiac surgery. Post-operative bleeding continued in spite of the use of blood products and aprotinin […]
This study illustrates one of the unusual situations in Medicine where evidence of drug efficacy in human preceded animal studies. After the publication of several case reports on the effectiveness […]
Nice overview, but inconsistency between recommendations in the figures and in the text. – V. Kretschmer
This is an interesting case report on the use of rFVIIa in treating uncontrollable surgical bleeding in a patient not known to have a pre-existing coagulopathy. The patient had a […]
A useful study (notwithstanding power) and review of current practices. – F. Regan and M. Contreras.
This survey reflects the current situation in England and North Wales, where the prevailing opinion is that only the use of blood components is state of the art. There is […]
This article starts with a general overview on mechanism of action, uses and safety of rFVIIa as well as the hemostatic disorders which are associated with liver disease. It states […]
This is a relatively new area for using rFVIIa, which is to treat uncontrolled haemorrhage in patients with severe trauma, following the earlier report of using rFVIIa successfully in treating […]
This is a new open-label study, which showed efficacy of rFVIIa in normalising prothrombin time and effective control of bleeding esophageal varices in cirrhotic patients, in addition to safety in […]
Having a sound and reproducible animal model to test the value of an existing therapy beyond its initial application is certainly a step forward. Kheirabadi and associates have taken this […]
This inovative work bears watching. Potential applications include minimally invasive, i.e., laparoscopic, approaches to control of traumatic liver injury. – R. K. Spence.
NATA: Network for the advancement of Patient Blood Management, Haemostasis and Thrombosis
MISSION: Providing a multidisciplinary forum for dialogue between haematologists, transfusion medicine specialists, anaesthesiologists, intensive care and emergency physicians, surgeons, perfusionists, nurses, biomedical scientists and ther healthcare professionals.
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