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Gene therapy for the hemophilias.

This is a good paper on the current state of affairs with gene therapy in hemophilia, reviewing the currently available vectors and the challenges facing gene therapy. It also reviews the ongoing clinical trials in this field. – M. Aldouri.

Mechanism of factor VIIa-dependent coagulation in hemophilia blood.

The mechanism of inducing hemostasis by factor VII (FVII) in hemophilia patients with inhibitors is not fully understood. Tissue factor (TF) and FVII are required to form a small concentration of thrombin (initiation phase) followed by increased activation of clotting factors and formation of a solid clot (propagation phase). This paper studies a model for […]