Hydroxyethyl starch (HES) 130/0.4 provides larger and faster increases in tissue oxygen tension in comparison with prehemodilution values than HES 70/0.5 or HES 200/0.5 in volunteers undergoing acute normovolemic hemodilution.
This prospective randomized double-blinded crossover study demonstrated that hydroxyethyl starch specifications (in vitro molecular weight, degree and pattern of substitution) could significantly alter muscular tissue oxygen tension used as an indicator of blood rheology. The better results obtained with HES 130/0.4 might be attributed to the optimum “in vivo” molecular size achieved by this hydroxyethyl […]
Worth a close look for those with a specialist interest in this area. Adds to a fast growing body of literature on the various effects of i.v. solutions on coagulation in-vitro. We wait with baited breath for the clinical studies. – Monty Mythen There are two major disturbing points about this article. Firstly, the main […]
Possible role of recombinant activated factor VII (RFVIIa) in the control of hemorrhage associated with massive trauma.
This is a report on the largest series on the use of rFVIIa in treating patients suffering from uncontrolled bleeding as a result of trauma in spite of surgical treatment and blood transfusion. There were 19 patients who received 1-3 doses of rFVIIa, and bleeding was controlled in 15 of them. Transfusion requirement was reduced, […]
This is a relatively new area for using rFVIIa, which is to treat uncontrolled haemorrhage in patients with severe trauma, following the earlier report of using rFVIIa successfully in treating bleeding in a soldier who suffered with bullet injur (Kenet et al., Lancet 1999;354:1879). rFVIIa was effective in controlling bleeding and resulted in significant reduction […]