Gene therapy for the hemophilias.

This is a good paper on the current state of affairs with gene therapy in hemophilia, reviewing the currently available vectors and the challenges facing gene therapy. It also reviews the ongoing clinical trials in this field. – M. Aldouri.

Influence of cell-free Hb on local tissue perfusion and oxygenation in acute anemia after isovolemic hemodilution.

This experimental study shows that, in hamsters, exchange transfusion with polymerized bovine hemoglobin to a hemoglobin content of 6.7 g/dL failed to maintain tissue oxygenation and in-vivo functional capillary density (according to this reviewer, possibly because PBH caused vasoconstriction). The message is important: we know hemoglobin solutions can transport oxygen but clinicians will want to […]