Blood substitutes: the future is now.

Review articles are interesting but, unfortunately, do not add to existing knowledge. They can be more or less well documented and interesting for clinicians. The profusion of review articles on oxygen carriers contrasts with the little data from randomized controlled trials published recently. – Jean-Franois Hardy This article extensively (144 references) reviews the past, the […]

Increased rate of infection associated with transfusion of old blood after severe injury.

This is a very important topic. All logical aspects would seem to suggest that stored cellular blood components have an immune suppressive effect. However, it is questionable whether this study can really document this effect. The difference in the number of transfused older blood units in the first 12 hours between the patients developing infectious […]

Influence of storage on red blood cell rheological properties.

Growing evidence shows that transfusion of stored red cells may well harm patients. Studies are therefore necessary in order to help establish the reasons for this negative effect. Decrease of deformability of red cells during storage may be one explanation. Reduced perfusion of the capillary bed may be the consequence of reduced deformability of red […]