Tag: INHIBITORS

Managing uncontrolled hemorrhage in trauma and surgery: a novel and promising approach.

This is an introduction for a supplement to the Canadian Journal of Anesthesia reporting proceedings of a satellite symposium presented at the 2002 Canadian Anesthesiologists’ Society Annual Meeting. It highlights […]

Possible role of recombinant activated factor VII (RFVIIa) in the control of hemorrhage associated with massive trauma.

This is a report on the largest series on the use of rFVIIa in treating patients suffering from uncontrolled bleeding as a result of trauma in spite of surgical treatment […]

Efficacy of recombinant factor VIIa administered by continuous infusion to haemophilia patients with inhibitors.

This is an interesting study looking at the efficacy of administering rFVIIa in controlling bleeding in 43 episodes in 14 hemophilia patients with inhibitors. RFVIIa infusion was not effective in […]

The effect of recombinant factor VIIa on coagulopathic pigs with grade V liver injuries.

This study illustrates one of the unusual situations in Medicine where evidence of drug efficacy in human preceded animal studies. After the publication of several case reports on the effectiveness […]

Orthopaedic surgery in haemophilic patients with inhibitors: an overview.

This is an excellent review on a large series reporting the use of rFVIIa in orthopedic surgeries in patients with hemophilia A and B with inhibitors, in addition to a […]

Continuous infusion of coagulation factor products.

This is an interesting review on the use of continuous infusion of coagulation factor products over the last 11 years. It concludes that effects were favorable in comparison to intermittent […]

Early use of recombinant factor VIIa improves mean arterial pressure and may potentially decrease mortality in experimental hemorrhagic shock: A pilot study.

This is an interesting work showing the efficacy of rFVIIa in controlling post traumatic hemorrhage in an animal model, especially after the publication of several case reports of the effective […]

Effective hemostasis with rFVIIa treatment in two patients with severe thrombocytopenia and life-threatening hemorrhage.

This article reports 2 patients with severe thrombocytopenia and severe hemorrhage which did not respond to standard therapy and platelet transfusion, but responded quickly to administration of a single dose […]

Recombinant factor VIIa in the management of surgery and acute bleeding episodes in children with haemophilia and high responding inhibitors.

This study reports the effective use of rFVIIa in covering 20 surgical procedures in 12 patients with hemophilia VIII with high inhibitors, in addition to treating 6 episodes of severe […]

Massive pseudotumour resection with recombinant factor VIIa (NovoSeven) cover.

This is an interesting case report on the use of rFVIIa in covering surgical resection of a large right gluteal pseudo-tumor in a 32-year-old patient with severe hemophilia A and […]