A second-generation blood substitute (perflubron emulsion) increases the blood solubility of modern volatile anesthetics in vitro.
This article describes the blood solubility of isoflurane, sevoflurane and desflurane in blood containing increasing concentrations of Perflubron emulsion (within the expected clinical concentration and twice that). While the blood/gas partition coefficient increased for all anesthetics, the clinical effect is expected to be minimal since the perfluorochemicals will be present in very small concentrations, even […]
