The hemodynamic and metabolic effects of shivering during acute normovolemic hemodilution.

In this rather sophisticated experimental study, the authors observed that severe acute normovolemic hemodilution (target hemoglobin concentration of 5.2 g/dL) significantly reduced the ability of the anesthetized animals to sustain a major increase in tissue oxygen demand resulting from shivering. They also provided further evidence that in these conditions of increased oxygen demand, the heart […]