Hypotensive transfusion reactions can occur with blood products that are leukoreduced before storage.

The authors describe hypotensive transfusion reactions in 2 patients taking ACE inhibitors, in one case corresponding to the transfusion of leukodepleted autologous whole blood, and in the other with non-leukodepleted whole blood of acute normovolemic hemodilution. In both cases severe impairment of des-Arg-bradykinin could be demonstrated. The authors conclude that not only bedside filtration but […]