Blood substitutes: the future is now.

Review articles are interesting but, unfortunately, do not add to existing knowledge. They can be more or less well documented and interesting for clinicians. The profusion of review articles on oxygen carriers contrasts with the little data from randomized controlled trials published recently. – Jean-Franois Hardy This article extensively (144 references) reviews the past, the […]

Hemoglobin-based oxygen carriers.

This review article describes the nine different hemoglobin-based oxygen carriers that have been developed since the 1980s. Seven of them are currently being tested in phase II or phase III clinical trials. – Philippe Van der Linden A general, potentially useful, text on hemoglobin-based oxygen carriers for clinicians. Specific molecules are reviewed somewhat briefly. – […]

Hemoglobin-vesicles as oxygen carriers – Influence on phagocytic activity and histopathological changes in reticuloendothelial system.

A good basic science article demonstrating that a single dose of hemoglobin encapsulated in a phospholipid bilayer membrane injected in rats has a transient and acceptable effect on the reticuloendothelial system. Initially, the RES is depressed but function returns to normal as hemoglobin vesicles are cleared. Questions that remain relate to the effect of hemoglobin […]

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