Anemia is a significant problem for cancer patients, especially those receiving chemotherapy. Preventing or treating anemia in these patients has clear cut quality of life improvements for the patients AND their care givers. Glaspy et al. furthermore tackle the important issue of survival and venous thromboembolism in their review article. They convincingly make the case […]
This is an important observational study which points towards higher mobidity and mortality in patients with acute coronary syndromes who undergo transfusion. The results obtained, though not definitive due to the nature of the study, strongly suggest the need for a randomized controlled clinical trial of restrictive versus liberal transfusion in this patient population. – […]
Essential reading material. The largest PRCT of Albumin vs Saline in 7,000 critically ill patients in Australia and New Zealand. Concludes “no-difference” in 28 day mortality. Subset trends to excess mortality with Albumin in trauma and head injury (more intra-cerebral bleeds) and reduced mortality with Albumin in sepsis. For those of us that never use […]
The association of lowest hematocrit during cardiopulmonary bypass with acute renal injury after coronary artery bypass surgery.
Challenging data about correlation between hemodilution and acute renal injury (documented by increase of creatinine), however, seems only to be relevant in patients with overweight. – Volker Kretschmer
Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trial.
This study by Henke et al. is certainly provocative. It reports a poor disease free and overall survival in head and neck cancer patients receiving locoregional radiation therapy. What might explain this negative tumor and overall survival effect in this erythropoietin study when virtually every other erythropoietin study has not had such an observation? First […]
This retrospective study reviews the blood conservation strategy developed in patients undergoing infrarenal aortic surgery in a tertiary vascular unit from 1995 to 2001. The authors show that the judicious association of acute normovolemic hemodilution and intraoperative cell salvage combined with restrictive transfusion triggers and careful surgery can dramatically reduce the use of allogeneic blood […]
The authors studied a database of 1,915 patients who underwent isolated first time myocardial revascularization between 1994 and 1997 and found that blood transfusions during or after coronary artery bypass operations were associated with increased long-term mortality (risk ratio = 1.7; 95% confidence interval = 1.4 to 2.0). This retrospective database analysis is important and […]