This is a report on 4 patients who underwent liver transplant surgery in whom coagulopathy was corrected with treatment with rFVIIa, but 2 patients subsequently suffered with thrombotic complications. One […]
This is an informative single institution study comparing the outcome of 51 patients who received rFVIIa (2.4 or 4.8 mg) for severe bleeding following cardiac surgery with matched controls. All […]
This is a case report on 5 patients who suffered severe uncontrolled bleeding following surgery which failed to respond to transfusion of blood components and hemostatic drugs but eventually improved […]
This is a letter describing an experiment in which rFVIIa was mixed with platelets from a patient with Bernard-Soulier syndrome. Platelet function (aggregation) was shown to improve, in addition to […]
This is a single case report on the effectiveness of rFVIIa in controlling severe postoperative bleeding following repair of aortic artery dissection under conditions of cardiopulmonary bypass and deep hypothermic […]
This paper reports the use of rFVIIa in 81 patients who suffered with traumatic bleeding over a period of 30 months in a large trauma center. The center set guidelines […]
This is an editorial which emphasizes the role of rFVIIa in treating hemophilia patients with inhibitors to factors VIII or IX. It also highlights the increasing role of rFVIIa in […]
This is a very well designed large international study which studied efficacy and safety of rFVIIa in controlling upper gastrointestinal bleeding in cirrhotic patients. Eight doses of rFVIIa or placebo […]
The use of rFVIIa in conditions associated with disseminated intravascular coagulation (DIC) has always been an area of concern in view of the theoretical possibility of enhancing thrombotic complications. However, […]
This study gives further evidence on the effectiveness of factor VIIa in controlling bleeding in pediatric cardiac surgery. Nine children who had excessive postoperative bleeding received a single dose of […]
This is a comprehensive update review on the various indications for the use of rFVIIa in both hemophilic and nonhemophilic patients, reviewing the major published work in these areas.
The increasing success reported in the use of rFVIIa to control severe bleeding in surgery and trauma in hemophilia and non-hemophilia patients has made it necessary to formulate protocols and […]
Over the last seven years there has been increasing number of case reports and studies documenting the effectiveness and safety of using rFVIIa (NovoSeven) in treating non-hemophiliac patients with severe […]
This is a case report on using rFVIIa to control severe bleeding following orthotopic cardiac transplant with multiple previous cardiac surgeries. Bleeding was initially uncontrolled despite the use of continuous […]
This is an excellent and comprehensive review on the use of rFVIIa, its mechanism of action and various indications for its use in controlling bleeding in congenital and acquired coagulation […]
NATA: Network for the advancement of Patient Blood Management, Haemostasis and Thrombosis
MISSION: Providing a multidisciplinary forum for dialogue between haematologists, transfusion medicine specialists, anaesthesiologists, intensive care and emergency physicians, surgeons, perfusionists, nurses, biomedical scientists and ther heathcare professionals.
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