The use of recombinant factor VIIa for severe intractable bleeding during spine surgery.
This is a report on the effective use of rFVIIa in controlling postoperative surgical bleeding and coagulopathy in four patients who underwent multilevel spine surgery. Bleeding was not initially controlled […]
Improved hemostasis with superactive analogs of factor VIIa in a mouse model of hemophilia A.
This is an elegant paper which studied the hemostatic efficacy of different doses of rFVIIa and three of its analogs on controlling bleeding in mice with antibody induced hemophilia. There […]
Activation of platelets in whole blood by recombinant factor VIIa by a thrombin-dependent mechanism.
Recombinant factor VIIa (Novoseven) is now proven to be an effective hemostatic agent in hemophiliac patients with inhibitors, as well as in uncontrolled bleeding in surgical and trauma non-hemophiliac patients. […]
Increased local procoagulant action: a mechanism contributing to the favorable hemostatic effect of recombinant FVIIa in PLT disorders.
This paper reports the procoagulant effect of rFVIIa in experimental thrombocytopenia, and in thromboasthenic platelets due to natural or experimentally induced glycoprotein deficiency. It shows that rFVIIa improved fibrin deposition, […]
Possible role of recombinant activated factor VII (RFVIIa) in the control of hemorrhage associated with massive trauma.
This is a report on the largest series on the use of rFVIIa in treating patients suffering from uncontrolled bleeding as a result of trauma in spite of surgical treatment […]
Sequential treatment with bolus and continuous infusion of recombinant factor VIIa for hip arthroplasty in a patient with haemophilia A and inhibitor.
This is a case report on a hemophilia VIII patient with high titer inhibitor who underwent total hip replacement and treatment with rFVIIa. rFVIIa was given as bolus treatment for […]
Effect of recombinant activated factor VII on perioperative blood loss in patients undergoing retropubic prostatectomy: a double-blind placebo-controlled randomised trial.
This is an interesting and important controlled study on using rFVIIa electively in the beginning of major surgery to reduce blood loss and blood transfusion. Patients were divided into three […]
Activated recombinant factor VII for control of diffuse bleeding after implantation of ventricular assist device.
This is another case report on the use of rFVIIa in controlling excessive bleeding during open heart surgery. A 57 year old woman underwent implantation of bilateral ventricular assist device […]
Updates in the management of severe coagulopathy in trauma patients.
This is a very good review on the pathophysiological changes which occur following trauma and the associated coagulopathy. Thrombo-cytopenia, hypotheromia, acidosis, and fibrinolysis are among factors which lead to coagulopathy. […]
NovoSeven: mode of action and use in acquired haemophilia.
This is a very good review on the use and mechanism of action of rFVIIa in acquired hemophilia. It reviews the physiological coagulation pathway and the central role of factor […]
Haemorrhagic complications of thrombocytopenia and oral anticoagulation: is there a role for recombinant activated factor VII?
This paper reviews the existing evidence supporting the efficacy and safety of rFVIIa in treating bleeding manifestations in patients with thrombocytopenia or those with excessive anticoagulation with warfarin. Currently this […]
Intracerebral hemorrhage: natural history and rationale of ultra-early hemostatic therapy.
This is an interesting and challenging area for the use of rFVIIa at early stages of hemorrhagic stroke in order to prevent growth of hematoma which occurs in this type […]
Orthopaedic surgery in haemophilic patients with inhibitors: an overview.
This is an excellent review on a large series reporting the use of rFVIIa in orthopedic surgeries in patients with hemophilia A and B with inhibitors, in addition to a […]
Effective hemostasis with rFVIIa treatment in two patients with severe thrombocytopenia and life-threatening hemorrhage.
This article reports 2 patients with severe thrombocytopenia and severe hemorrhage which did not respond to standard therapy and platelet transfusion, but responded quickly to administration of a single dose […]
Successful use of recombinant factor VIIa for hemostasis during total knee replacement in a severe hemophiliac with high-titer factor VIII inhibitor.
This is another case report of a successful use of rFVIIa in covering knee replacement surgery in a patient with severe hemophilia A and high-titer inhibitor. rFVIIa was given at […]