A randomized comparison of every-2-week darbepoetin alfa and weekly epoetin alfa for the treatment of chemotherapy-induced anemia in patients with breast, lung, or gynecologic cancer.
An important trial by Schwartzberg et al. has recently been published in The Oncologist. In prospective manner, this trial tested the two erythropoietin preparations commonly used in the US, epoetin […]
Prognostic significance of perioperative blood transfusion in oral cavity squamous cell carcinoma.
The debate of blood transfusion and cancer recurrence continues in this study. The authors found LN status and >3 units of blood transfused to be poor prognostic factors, but this […]
Efficacy and safety of darbepoetin alfa in anaemic patients with lymphoproliferative malignancies: a randomized, double-blind, placebo-controlled study.
A nicely done placebo controlled trial of darbepoetin in anemic hematologic malignancy patients demonstrating darbepoetin’s efficacy and safety. – David H. Henry
Once-weekly epoetin beta is highly effective in treating anaemic patients with lymphoproliferative malignancy and defective endogenous erythropoietin production.
This is an important EPO trial in hematologic malignancy patients for two reasons. It demonstrates that lower EPO levels predict response… an observation not reproduced in solid tumor patients but […]
Response predicting factors to recombinant human erythropoietin in cancer patients undergoing platinum-based chemotherapy.
This is a well done study of anemic cancer patients on cisplatin chemotherapy that documents nicely that the best predictor of an ultimate good response to epoetin is an early […]
Double-blind, placebo-controlled, randomized phase III trial of darbepoetin alfa in lung cancer patients receiving chemotherapy.
Excellent design. – Patricia Ford
Bleeding from endometrial and vaginal malignant tumors treated with activated recombinant factor VII.
This is a case report of two female patients with severe vaginal bleeding following previous treatment of gynecological malignancies and no pre-existing coagulation factor deficiency. Bleeding was controlled with two […]
Place of normovolemic hemodilution in oncologic cervicofacial and ENT surgery. [Article in French]
This prospective study did not demonstrate a beneficial effect of acute normovolemic hemodilution (ANH) in patients undergoing cervicofacial and ENT surgery. However, it does not possess the statistical power to […]