The use of bovine hemoglobin glutamer-250 (Hemopure (R)) in surgical patients: Results of a multicenter, randomized, single-blinded trial.

The authors conducted a study on the safety of hemoglobin glutamer-250 in surgical patients. The protocol consisted of exposing (different) patients to increasing doses of hemoglobin glutamer-250 while safety was monitored. Control patients received Ringer’ lactate solution. The results are not unexpected. Basically, in these patients who bled on average 1.7 L during surgery, hemoglobin […]

The effects of hemoglobin glutamer-200 (Bovine) on the microcirculation in a canine hypovolemia model: A noninvasive computer-assisted intravital microscopy study.

The authors present a dog model of hemorrhage (similar to 40% blood loss) that will be useful for the evaluation of treatment(s) of severe hypovolemia. In this case, hemoglobin glutamer-200 was used to restore the circulating blood volume and oxygen carrying capacity. However, the authors’ conclusions are limited by the small number of dogs studied […]