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Small-volume resuscitation with HBOC-201: effects on cardiovascular parameters and brain tissue oxygen tension in an out-of-hospital model of hemorrhage in swine.

This experimental observational study reports that, in anesthetized pigs undergoing hemorrhage, small volume resuscitation (6 mL/kg) of a bovine hemoglobin based oxygen carrier can restore mean arterial pressure and cardiac output while improving brain oxygen tension. – Philippe Van der Linden This is a second article on the effect of HBOC-201 for the acute treatment […]

HBOC-201 improves survival in a swine model of hemorrhagic shock and liver injury.

This experimental study highlights the potential beneficial therapeutic effect of a hemoglobin-based oxygen carrier (HBOC) used as a resuscitation fluid during severe traumatic shock. In contrast to colloid (high molecular weight hydroxyethyl starch) based resuscitation, a similar volume of HBOC from bovine origin prevented exsanguination cardiac arrest, allowing for significantly higher long term (96 hr) […]