Small-volume resuscitation with HBOC-201: effects on cardiovascular parameters and brain tissue oxygen tension in an out-of-hospital model of hemorrhage in swine.
This experimental observational study reports that, in anesthetized pigs undergoing hemorrhage, small volume resuscitation (6 mL/kg) of a bovine hemoglobin based oxygen carrier can restore mean arterial pressure and cardiac […]
HBOC-201 improves survival in a swine model of hemorrhagic shock and liver injury.
This experimental study highlights the potential beneficial therapeutic effect of a hemoglobin-based oxygen carrier (HBOC) used as a resuscitation fluid during severe traumatic shock. In contrast to colloid (high molecular […]
Comparison of the effects of a 50% exchange-transfusion with albumin, hetastarch, and modified hemoglobin solutions.
This preliminary (considering phase III studies have been completed or are underway) study in rats adds little to what has already been published on this issue in more elaborate animal […]
Hypotensive resuscitation using a polymerized bovine hemoglobin-based oxygen-carrying solution (HBOC-201) leads to reversal of anaerobic metabolism.
Interesting article evaluating the place of a hemoglobin-based oxygen-carrying solution in the resuscitation of severe hemorrhagic shock. – P. Van der Linden.