The main adverse effects to be expected from the use of rFVIIa is the occurrence of thromboembolic complications. This study reviews the occurrence of adverse effects reported to the FDA […]
Cardiac surgery is often associated with excessive blood component transfusion especially with complex and repeat procedures, and is therefore an obvious target for blood saving measures. There have been several […]
This is a small series of case reports on using rFVIIa in treating severe perioperative hemorrhage in 8 patients undergoing major vascular surgeries, contributing to effective hemostasis in 7 of […]
The etiology of severe hemorrhage associated with trauma includes coagulopathy, hypothermia, acidosis, as well as platelet dysfunction, in addition to the direct effect of trauma itself. This important large international […]
This article reviews the mechanism of action of rFVIIa and outlines its off-label use in management of perioperative bleeding and intracranial hemorrhage. Authors review the paper of Raivio et al […]
This is one center experience on the use of rFVIIa to treat severe postoperative bleeding following cardiac surgery after failure of conventional therapy with blood components and hemostatic agents. Bleeding […]
This editorial reviews the use of rFVIIa in management of surgical and post-partum hemorrhage and highlights that in spite of anecdotal evidence from published case reports and small series of […]
This is the largest published series so far on the use of rFVIIa in controlling severe post-partum hemorrhage (PPH). Good and partial response was observed in 11 out of 12 […]
This randomized study did not show significant difference between perioperative blood loss or blood transfusion requirement by prophylactic use of rFVIIa in patients with normal hemostasis undergoing pelvic surgery. No […]
This case report illustrates the efficacy and benefit of using rFVIIa in controlling severe bleeding associated with trauma which resulted in severe pelvic and sacral fracture. The authors advocate further […]
This is an extremely important, long-awaited study on the effect of rFVIIa in management of intracerebral haemorrhage. It is a double-blind, placebo-controlled study which enrolled 399 patients into control placebo […]
This editorial reviews the work of Mayer et al. on the use of rFVIIa in patients who suffer intracerebral hemorrhage and gives a new hope of therapy which can prevent […]
Recombinant factor VIIa has been found to be effective in controlling bleeding associated with inherited and acquired platelet dysfunction, such as thromboasthenia and renal failure. In this case report, rFVIIa […]
This is an interesting case report on the efficacy of rFVIIa in controlling bleeding in a complex situation of trauma, intracranial hemorrhage, and autoimmune thrombocytopenia. – Maadh Aldouri
Liver surgery is known to be associated with significant blood loss and high requirement of blood products support, and rFVIIa has been shown in a few case reports to reduce […]
NATA: Network for the advancement of Patient Blood Management, Haemostasis and Thrombosis
MISSION: Providing a multidisciplinary forum for dialogue between haematologists, transfusion medicine specialists, anaesthesiologists, intensive care and emergency physicians, surgeons, perfusionists, nurses, biomedical scientists and ther healthcare professionals.
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