Important study showing that more than one third of donors show no symptoms although having viremia and transmitting West Nile virus. Therefore, nucleic-based assays for West-Nile Virus are necessary in countries with West Nile virus epidemiology. Although such a test was quickly introduced in the US, the West Nile Virus is an example for the […]
Very important is the conclusion that mistransfusions are the main risk of blood transfusions. Means of limiting these serious hazards should therefore have priority in blood safety. – Volker Kretschmer
Discussion of very recent literature, calculation of current risk of transfusion transmitted viral infections after introduction of NAT-HCV and NAT-HIV. Determination of cost/benefit of introduction of NAT. Conclusive statement that p24 antigen testing should be omitted after introducztion of NAT. – Volker Kretschmer
In this observational study, the authors report their experience with the use of acute normovolemic hemodilution in cardiac surgery patients. – Philippe Van der Linden This article convincingly shows that ANH in patients undergoing cardiac surgery significantly reduces the need for allogeneic blood transfusion. Autologous blood removed ranged from 1 (70%) to 2-5 (30% of […]
This case control cohort study reports that the efficacy of acute normovolemic hemodilution as a blood conservation technique appears limited due to the usually poor clinical status of patients undergoing femoro-distal bypass grafts. – Philippe Van der Linden
This is a very important paper in two ways. First, it highlights ongoing activation of hemostasis in the postoperative period as demonstrated by the control group. The scale of Figure 1 blurs the very low activity in patients with or without a low dose of antithrombin (AT). This period of activation may even exist longer […]
The authors studied a database of 1,915 patients who underwent isolated first time myocardial revascularization between 1994 and 1997 and found that blood transfusions during or after coronary artery bypass operations were associated with increased long-term mortality (risk ratio = 1.7; 95% confidence interval = 1.4 to 2.0). This retrospective database analysis is important and […]
Interesting, but very rare adverse reaction that needs not be treated as long as no bacterial infection complicates the situation. Then antibiotics are the therapy of choice, and not granulocyte colony stimulating factor as used in the report, because granulocytopoiesis is normal. – V. Kretschmer
Reduction in erythropoietin doses by the use of chronic intravenous iron supplementation in iron-replete hemodialysis patients.
The authors from Taiwan state that they used “Ferrum Hausmann, a ferric polymaltose complex.” Under the same name (Ferrum Hausmann), iron saccharate (identical to iron sucrose) has been licensed in several European countries. The confusion concerning various iron sugar compounds gets even greater when one considers that “ferric polymaltose complex” was reported as being used […]
The article demonstrates that the decision towards autologous blood donation (ABD) does not, in the majority of cases, depend on the hemoglobin values but on additional health risk factors. There was even an increase of ABD from 1995/96 to 1998/99, which was not the case, for example, in Europe. Otherwise, the data confirm the generally […]
Coronary artery bypass grafting surgery without the routine application of blood products: is it feasible?
The results of this study are rather surprising. The control group receiving FFP required significantly more red cell concentrates (RBCs). One of the reasons explaining this could be that the patients did not benefit from the FFP because it was not indicated. Besides, an “educational effect” may have influenced surgery and the indication of RBC […]