Transmission of West Nile Virus through blood transfusion in the United States in 2002.

Important study showing that more than one third of donors show no symptoms although having viremia and transmitting West Nile virus. Therefore, nucleic-based assays for West-Nile Virus are necessary in countries with West Nile virus epidemiology. Although such a test was quickly introduced in the US, the West Nile Virus is an example for the […]

US NAT yield: where are we after 2 years?

Discussion of very recent literature, calculation of current risk of transfusion transmitted viral infections after introduction of NAT-HCV and NAT-HIV. Determination of cost/benefit of introduction of NAT. Conclusive statement that p24 antigen testing should be omitted after introducztion of NAT. – Volker Kretschmer

The use of acute normovolemic hemodilution in patients undergoing cardiac surgery.

In this observational study, the authors report their experience with the use of acute normovolemic hemodilution in cardiac surgery patients. – Philippe Van der Linden This article convincingly shows that ANH in patients undergoing cardiac surgery significantly reduces the need for allogeneic blood transfusion. Autologous blood removed ranged from 1 (70%) to 2-5 (30% of […]

Effect of blood transfusion on long-term survival after cardiac operation.

The authors studied a database of 1,915 patients who underwent isolated first time myocardial revascularization between 1994 and 1997 and found that blood transfusions during or after coronary artery bypass operations were associated with increased long-term mortality (risk ratio = 1.7; 95% confidence interval = 1.4 to 2.0). This retrospective database analysis is important and […]

Reduction in erythropoietin doses by the use of chronic intravenous iron supplementation in iron-replete hemodialysis patients.

The authors from Taiwan state that they used “Ferrum Hausmann, a ferric polymaltose complex.” Under the same name (Ferrum Hausmann), iron saccharate (identical to iron sucrose) has been licensed in several European countries. The confusion concerning various iron sugar compounds gets even greater when one considers that “ferric polymaltose complex” was reported as being used […]

Transfusion practices for elective orthopedic surgery.

The article demonstrates that the decision towards autologous blood donation (ABD) does not, in the majority of cases, depend on the hemoglobin values but on additional health risk factors. There was even an increase of ABD from 1995/96 to 1998/99, which was not the case, for example, in Europe. Otherwise, the data confirm the generally […]