The risk associated with aprotinin in cardiac surgery.
To read the commentary by Dean A. Fergusson, MHA, PhD, from the University of Ottawa Centre for Transfusion Research, please click here. See also the comment by Robert J. Porte, […]
Tag: safety
Thromboembolic adverse events after use of recombinant human coagulation factor VIIa.
The main adverse effects to be expected from the use of rFVIIa is the occurrence of thromboembolic complications. This study reviews the occurrence of adverse effects reported to the FDA […]
Comparative thrombotic event incidence after infusion of recombinant factor VIIa versus factor VIII inhibitor bypass activity.
Thromboembolic (TE) events are recognized but rare complications associated with the use of factor VIII inhibitor bypass activity (FEIBA) and rFVIIa. This study looks at the reported TE events of […]
Recombinant factor VIIa: how safe is the stuff?
This editorial highlights the safety of rFVIIa in view of the relatively small number of thrombotic complications reported with the use of over 700,000 doses of rFVIIa. In many of […]
Transfusion medicine service policies for recombinant factor VIIa administration.
The increasing success reported in the use of rFVIIa to control severe bleeding in surgery and trauma in hemophilia and non-hemophilia patients has made it necessary to formulate protocols and […]
Preoperative acute normovolemic hemodilution: a meta-analysis.
This meta-analysis reviewed 42 trials evaluating the efficacy and safety of preoperative acute normovolemic hemodilution (ANH). The authors reported that the risk of allogeneic transfusion was similar among patients receiving […]
Patient safety and blood transfusion: new solutions.
Interesting paper on new solutions for making transfusions safer. The only aspect which is missing is a better education of the staff involved in hemotherapy, which is even more important […]
Transfusion risks of yesterday and of today. [Article in French]
Very important is the conclusion that mistransfusions are the main risk of blood transfusions. Means of limiting these serious hazards should therefore have priority in blood safety. – Volker Kretschmer
Tolerance to acute isovolemic hemodilution: effect of anesthetic depth.
This is a very important contribution to the field of acute normovolemic hemodilution (ANH), because it clearly indicates the need of adjusting the depth of anesthesia in dependence upon the […]
Experience with use of recombinant activated factor VII.
This is a case report of successfully treating hemorrhage with rFVIIa in four patients with factor VIII and one with factor V inhibitor. One patient was initially treated with APCC […]
The use of bovine hemoglobin glutamer-250 (Hemopure (R)) in surgical patients: Results of a multicenter, randomized, single-blinded trial.
The authors conducted a study on the safety of hemoglobin glutamer-250 in surgical patients. The protocol consisted of exposing (different) patients to increasing doses of hemoglobin glutamer-250 while safety was […]
Effectiveness of combined blood conservation measures in thoracic aortic operations with deep hypothermic circulatory arrest.
Note: See also the useful invited commentary by John A. Elefteriades on pages 743-4. – F. Regan and M. Contreras.
Legal, financial, and public health consequences of HIV contamination of blood and blood products in the 1980s and 1990s.
The reviewer has only read the summary. The article emphasizes something that is well known. However, practically no valid data from developing countries is used as they do not even […]
Inhibition of fibrinolysis by recombinant factor VIIA in plasma from patients with severe hemophilia A.
This is a very interesting article which casts new light on the mechanism of hemostasis of rFVIIa in hemophiliac patients with inhibitors to factor VIII. rFVIIa is known to exert […]
A double-blind study to evaluate the safety of recombinant human hemoglobin in surgical patients during general anesthesia.
The authors evaluated the safety profile of escalating doses of rHb1.1 in patients undergoing surgery under general anesthesia. The adverse effects observed (and the authors’ conclusions) are those that one […]
