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Hydroxyethyl starch (HES) 130/0.4 provides larger and faster increases in tissue oxygen tension in comparison with prehemodilution values than HES 70/0.5 or HES 200/0.5 in volunteers undergoing acute normovolemic hemodilution.

This prospective randomized double-blinded crossover study demonstrated that hydroxyethyl starch specifications (in vitro molecular weight, degree and pattern of substitution) could significantly alter muscular tissue oxygen tension used as an indicator of blood rheology. The better results obtained with HES 130/0.4 might be attributed to the optimum “in vivo” molecular size achieved by this hydroxyethyl […]

Blood substitutes: the future is now.

Review articles are interesting but, unfortunately, do not add to existing knowledge. They can be more or less well documented and interesting for clinicians. The profusion of review articles on oxygen carriers contrasts with the little data from randomized controlled trials published recently. – Jean-Franois Hardy This article extensively (144 references) reviews the past, the […]

Effects of ultra-purified polymerized bovine hemoglobin on local tissue oxygen tension in striated skin muscle – An efficacy study in the hamster.

This is another study on the potential benefits of an oxygen carrier (ultrapurified polymerized bovine hemoglobin solution) on tissue perfusion after hypervolemic infusion or exchange transfusion of 50% of blood volume in a hamster model. The authors have shown that the infusion of the hemoglobin solution actually decreases (slightly) mean tissue pO2 but homogenizes local […]