Hyperchloraemic metabolic acidosis during plasma volume replacement. [Article in French]
Article in French limits broader reading. C’est la vie! Some great tables and diagrams, and the reference list is excellent. However, lag time to publication of paper journals means that […]
The use of bovine hemoglobin glutamer-250 (Hemopure (R)) in surgical patients: Results of a multicenter, randomized, single-blinded trial.
The authors conducted a study on the safety of hemoglobin glutamer-250 in surgical patients. The protocol consisted of exposing (different) patients to increasing doses of hemoglobin glutamer-250 while safety was […]
Recombinant factor VIIa in the management of surgery and acute bleeding episodes in children with haemophilia and high responding inhibitors.
This study reports the effective use of rFVIIa in covering 20 surgical procedures in 12 patients with hemophilia VIII with high inhibitors, in addition to treating 6 episodes of severe […]
Survey of the use of whole blood in current blood transfusion practice.
This survey reflects the current situation in England and North Wales, where the prevailing opinion is that only the use of blood components is state of the art. There is […]
Limited effectiveness of intraoperative autotransfusion in major back surgery.
This is a helpful report to design an autologous transfusion strategy. The conclusion is that one must extend blood salvage to the postoperative period or combine intraoperative blood salvage with […]
Time-related changes of collected shed blood in autologous retransfusion after total knee arthroplasty.
The prolonged collection of drained blood is problematic due the risk of bacterial contamination and to the exponential proliferation of bacteria at room temperature. Some countries prohibit collection exceeding 6 […]
Oxygen transport dynamics of acellular hemoglobin solutions in an isovolemic hemodilution model in swine.
It does not come as a surprise that hemoglobin solutions improve oxygen delivery and consumption in severely anemic swine. However, changes in P-50 do not appear to modify oxygen dynamics […]
Surgery-associated acquired hemophilia A.
This article raises awareness of the occurrence of acquired FVIII inhibitor postoperatively. One patient developed an inhibitor to FVIII 4 days after surgery for correction of abdominal hernia and bleeding […]
Intraoperative cell salvage in radical retropubic prostatectomy.
This article attempts a risk evaluation with only 62 patients. Unfortunately, statistics tell us that, even to show a risk increase (e.g., of metastasis) by as much as 10%, one […]
Survival, function, and hemolysis of shed red blood cells processed as nonwashed blood and washed red blood cells.
This paper adds further evidence that intraoperatively salvaged blood is of high quality with regard to RBC function and viability. This is especially true for washed RBCs. The hemolysis and […]
Is homologous blood transfusion a risk factor for infection after hip replacement?
Note: It is difficult to ascertain transfusion as a factor entirely separate from co-morbidity. – F. Regan and M. Contreras.
Rationale for the use of high dose rFVIIa in a high-titre inhibitor patient with haemophilia B during major orthopaedic procedures.
This is a case report of a child with severe hemophilia B and high titer factor IX inhibitor who was not achieving good hemostasis on conventional doses of rFVIIa. Pharmacokinetic […]
Release of interleukin-10 by reinfusion of salvaged blood after knee arthroplasty.
Another confirmation that cell washing is essential to eliminate mediators contaminating wound blood, and that changes in interleukin levels are mainly dependent on other factors. – E. Hansen.
Randomized comparison of ultrasonic vs clamp transection of the liver.
Takayama and his colleagues show us another step forward in the development of optimal techniques for liver resection. Their message emphasizes that the skill of the surgeon remains critical in […]
Influence of a new hydroxyethylstarch preparation (HES 130/ 0.4) on coagulation in cardiac surgical patients.
Note that volumes of Gelatine and Starch required to maintain CVP are no different between two groups, suggesting that the two solutions are equally effective as plasma volume expanders. However, […]