This study illustrates one of the unusual situations in Medicine where evidence of drug efficacy in human preceded animal studies. After the publication of several case reports on the effectiveness of rFVIIa in controlling traumatic bleeding, this study proves its efficacy in reducing bleeding after grade V liver injury in hypothermic dilutionally coagulopathic pigs, as […]
Epinephrine versus epinephrine plus fibrin glue injection in peptic ulcer bleeding: a prospective randomized trial.
A useful study (notwithstanding power) and review of current practices. – F. Regan and M. Contreras.
Inhibition of fibrinolysis by recombinant factor VIIA in plasma from patients with severe hemophilia A.
This is a very interesting article which casts new light on the mechanism of hemostasis of rFVIIa in hemophiliac patients with inhibitors to factor VIII. rFVIIa is known to exert its hemostatic effect by binding with tissue factor and activation of factors IX, X and XI, and formation of thrombin burst. This study shows that […]
Development of an animal model for assessment of the hemostatic efficacy of fibrin sealant in vascular surgery.
Having a sound and reproducible animal model to test the value of an existing therapy beyond its initial application is certainly a step forward. Kheirabadi and associates have taken this step for us in a vascular surgery model for fibrin sealant use. Their results are consistent with what we have learned anecdotally in clinical practice […]