Tag: TISSUE FACTOR

The interaction between platelets and factor VII/VIIa.

This is a clearly written article detailing the mechanism of action of rFVIIa and its interaction with tissue factor and platelets leading to its hemostatic effect in hemophilia patients with […]

Recombinant activated factor VII: its mechanism of action and role in the control of hemorrhage.

This is an overview on the mechanism of action of rFVIIa and its role in hemostasis. rFVIIa directly activates FX, increases thrombin activation on activated platelets, and leads to generation […]

Possible role of recombinant activated factor VII (RFVIIa) in the control of hemorrhage associated with massive trauma.

This is a report on the largest series on the use of rFVIIa in treating patients suffering from uncontrolled bleeding as a result of trauma in spite of surgical treatment […]

Activated recombinant factor VII for control of diffuse bleeding after implantation of ventricular assist device.

This is another case report on the use of rFVIIa in controlling excessive bleeding during open heart surgery. A 57 year old woman underwent implantation of bilateral ventricular assist device […]

Acquired factor VII deficiency in hematopoietic stem cell transplant recipients.

This is an interesting and new case report on the occurrence of acquired factor VII deficiency in eight patients following intensive chemotherapy and/or radiotherapy followed by hematopoietic stem cell transplantation […]

Effective hemostasis with rFVIIa treatment in two patients with severe thrombocytopenia and life-threatening hemorrhage.

This article reports 2 patients with severe thrombocytopenia and severe hemorrhage which did not respond to standard therapy and platelet transfusion, but responded quickly to administration of a single dose […]

Recombinant factor VIIa improves clot formation but not fibrolytic potential in patients with cirrhosis and during liver transplantation.

Etiology of bleeding in cirrhotic patients during surgery is multifactorial, and its management includes several measures such as replacement of coagulation factors and platelets as well as the use of […]

Potential role for rFVIIa in transfusion medicine.

This a thorough and comprehensive review on the mechanism of action and various indications and uses of rFVIIa, highlighting the pivotal role of factor VII in hemostasis, as well as […]

Inhibition of fibrinolysis by recombinant factor VIIA in plasma from patients with severe hemophilia A.

This is a very interesting article which casts new light on the mechanism of hemostasis of rFVIIa in hemophiliac patients with inhibitors to factor VIII. rFVIIa is known to exert […]